Earth Day 2017: Onwards and upwards

Posted on April 20, 2017 by Kerri Donohue

“Unless someone like you cares a whole awful lot,
nothing is going to get better. It’s not.”
― Dr. Seuss, The Lorax

Less than fifty years ago on April 22, 1970, the modern day environmental movement was born and the first Earth Day was celebrated. Rachel Carson, scientist and writer, is credited with raising environmental awareness with the publication of her book, Silent Spring, in 1962. That publication, the political climate of the time, and a series of human-caused environmental disasters led twenty million people to come together and rally for the protection of the environment. On April 22, 2017 it is estimated that over 200 million people worldwide will follow suit and celebrate Earth Day. (more…)

Heritability: what it means and why it’s important

Posted on April 11, 2017 by Mark Juers

A cluster of points is plotted on a coordinate plane with x values randing from 155 to 180 and y values ranging from 160 to 180. A best-fit line is plotted against them — Simulated data for 1000 families representing heritability for some trait, say height in centimeters. Each point represents the mean of the offspring plotted against the mean of the parents. In this case, heritability, or the slope of the line, is 0.60.

In a previous post, I briefly discussed something called genetic correlation and how this might be important for the evolution of a trait. Now, I hope to further clarify that concept and add to that a discussion of a very important concept in evolutionary biology—heritability—and tie it back to my initial discussion of the evolution of pesticide resistance.

Consider your siblings or the siblings of a friend and you will likely observe that inheritance of a trait is not a binary distinction. In other words, it is not always as simple as either having or not having a trait from a parent. Chances are, neither you nor your siblings are exactly the same height as either of your parents, or their mean (or average). This is because height–and virtually every other quantitative trait, or one that is variable along some continuum—has an associated heritability (or h²). As an aside, the notation of this is a bit confusing; we’re not actually squaring anything, but this notational weirdness is an accident of history. At any rate, the most straightforward, but perhaps least intuitive way of thinking about heritability is that it is the slope of the best-fit linear regression of offspring trait means on parent trait means. If your parents’ mean height is x, and you and your siblings’ mean height is y, and you plot this as a point (x,y) on a coordinate plane along with those of many other families, heritability is the slope of the line that most closely follows this cluster of points. Incidentally, the technique of linear regression taught in introductory statistics was developed for just this purpose. (more…)

How do you get adolescents to meditate? Part 1

Posted on April 4, 2017 by Ryan G. Erbe

In the health behavior field, we often focus on what health professionals should help young people avoid, such as risk behaviors, rather than positive health behaviors that we could help them acquire. So, when I decided to start working on my PhD, and I wanted to study health promoting behaviors, I knew I would be met with some resistance or challenges from the more well established health behavior researchers. Fortunately, I ended up at Indiana University where this type of thinking is not only accepted, but encouraged within the Applied Health Science Department.

The adolescent period has traditionally been viewed as a time in life to ‘just survive’. Remember the three As of adolescence- Acne, Awkward, and Apathetic. However, due to advances in neuroscience, researchers are now singing a different tune when studying adolescents. Traditionally, it was thought that a majority of the development that occurs in the brain happens during early childhood. The neuroimaging studies from the last 10-15 years suggest otherwise (Giedd, 2008). Around age 12, the brain goes through another massive restructuring as it eliminates connections between brain cells that aren’t used and strengthens those that are. (more…)

Nanomaterials that inhibit bacterial growth

Posted on March 28, 2017 by Kimberly McCoy

Nanomaterials are fast becoming the materials of the future. Just this year three scientists were awarded the Nobel Prize in Chemistry for their work in understanding Molecular Machines. Each time period in human history has been defined by the materials that we are able to harness–the Stone Age, the Bronze Age, and now, the Nanomaterial Age? The better scientists are able to design, create, and manipulate nanoscale objects, the more advanced our technology will become.

But let’s back up a little. What is the nanoscale? You would be correct if you said really, really, really small, but let’s be more precise about it. A nanometer is 0.000000001 meters or, in scientific notation, 1 × 10^-9 meters (move the decimal over 9 spaces). As you can see from the image below, you can’t see nanoscale objects with the naked eye, but they are still much bigger than individual molecules or x-rays. (more…)

The lessons of science past: Learning about the history of science

Posted on March 22, 2017 by Chris ChoGlueck

Even though the geocentric model of our universe is outdated, it is still useful for illustrating the burdens facing many young scholars in the U.S. Midwest. Moving to a new location each year, the Junto makes it easier for historians of science to get out of the seemingly “outer orbit” of the Midwest by bringing the “center of the universe” to them. Logo modeled on a diagram in Peter Apian’s Cosmographia, 1524.

As a reader on this blog, you probably enjoy learning about science. But how much do you know about its history? If you’re a scientist, do you know where your field came from? There are fascinating stories behind the instruments you use and the journals you read. If you’re not a scientist, do you know about the connections between surgery and warfare? Or how computers came to be both everywhere and invisible? This is where historians of science come in. We inform current-day scientists by tracing their present work to past discoveries and reflecting on the lessons from these successes and failures. We can tell you how scientific knowledge has changed over time, the stories of the people who were behind it, and how it shaped and was shaped by society. (more…)

Why is there no cure for cancer, and what are we doing about it?

Posted on March 21, 2017 by Taylor Nicholas

Have you ever wondered why there is no “cure” for cancer? Conspiracy theories aside, a cure for cancer doesn’t exist because it is biologically impossible. The reason is simple: just as no two people are identical, no two cancers are the same. Each case of cancer may be genetically distinct, which means that the driver mutations that caused the cancer can differ from patient to patient. For this reason, different treatments are required for each type of cancer, making it unfeasible to think that there will someday be a “one-size-fits-all” cure for cancer.

Given such diversity among cancers, what is the best strategy for scientists to target specific driver mutations? Treatments that are tailored to a specific mutational subtype of a disease are called precision medicines. Precision medicines are designed with consideration of a patient’s genetics, lifestyle, and environment in order to more effectively treat individual cancer cases. In 2016, President Obama launched a $215 million Precision Medicine Initiative to fund advances in this area. (more…)

The need of our times: Support for fundamental science research

Posted on March 14, 2017 by Karna Desai

If you are an undergraduate student, you probably share some attributes with other readers of this blog. You are likely a millennial, meaning that you may not remember the fall of the Berlin wall, and to you, the space race is a distant past.

Federal funding for “fundamental” or “basic” science research was at the all-time high in the 1960’s (see Figure 1), but it has declined since then. The stagnation of funding in recent years is alarming, because the science, technology, engineering, and math (STEM) workforce is forecast to hit a new peak. Consumers love 21st-century technologies, like smartphones and smart TVs, but what will 22nd-century technology look like with diminished federal funding? Because we regularly hear about budget cuts, we fail to recognize that science funding in the U.S. is not keeping up with that of other countries (see Figure 2). (more…)

Chemical keys to brain function

Posted on March 7, 2017 by Noah Zarr

According to both popular science and drug commercials, the brain is a mess of chemicals. Imbalances in these chemicals are responsible for a variety of ailments from depression to addiction. However, there’s rarely any mention of how these chemicals are related to neural activity. For instance, why is dopamine often rewarding, and why is serotonin related to depression?

A molecule of glutamate depicted as differently colored spheres representing atoms connected by cylinders representing molecular bonds. — The molecular structure of glutamate, an excitatory neurotransmitter. Glutamate unlocks “doors” in many neurons that allow charged particles into the cell, making it more likely to fire. Image by SubDural12 / CC BY.

To answer such questions, let’s back up a bit. The brain receives, processes, and sends information in the form of electrical signals sent to and from neurons. Like all cells, neurons have a membrane which separates the inside of the cell from the outside. They also have molecular machinery that keeps the inside of the cell more electrically negative than the outside of the cell by pumping out certain electrically charged particles and allowing others in. Like a wall in a building, the membrane is solid in most places but also contains tiny doors. When the right molecule fits into part of the door, like a key into a lock, the door opens and lets in particles which can make the inside more or less negative. (more…)

Hidden figures, no more

Posted on February 28, 2017 by Guest Contributor

A banner that reads: ScIU Commemorating Black History Month

This is the second installment of ScIU theme posts for Black History Month. The authors are ScIU guest writer Marvin Q. Jones, Jr., a graduate student in IU’s Department of Mathematics from Newport News, VA; and Steve Hussung, also a graduate student in IU’s Department of Mathematics. Check out our other Black History Month post here.

A photograph of Margot Lee Shetterly, who is elegantly dressed and standing in front of a backdrop that reads, “Hidden Figures”. — Margot Lee Shetterly celebrating the release of her film at the SVA Theatre in New York.

Hidden Figures, a recently-released movie that captures the pioneering contributions of black women to the space program, is both necessary and incredible — everyone should see this film.

We’re going to look at some of the mathematics (and physics) in the movie to talk about space flight. We will emphasize the magnitude of what black female scientists, formerly hidden figures, contributed to the space race and NASA’s space program. Along the way, there may be some spoilers. (more…)

A short interview with Dr. Jonathan Schlebach

Posted on February 21, 2017 by Victoria Kohout

This past August Indiana University welcomed a new addition to its chemical biology research faculty, Dr. Jonathan Schlebach. Dr. Schlebach came to IU following a post-doctoral position at Vanderbilt University in Nashville, Tennessee, to begin setting up his own research program and teaching graduate and undergraduate courses. He offers some insight on what his research program will cover, his career choice, and his advice to students interested in looking into scientific research. (more…)