Six Indiana University-led technologies and methods have recently received patents from the U.S. Patent and Trademark Office. These innovations include an antiviral drug treatment for HPV, as well as methods for activating T cells in vitro, processing speech, enhancing the study of the gut microbial ecosystem, analyzing lipoproteins through the use of mass spectrometry and providing a transportation network infrastructure for aerial autonomous vehicles.
Below is information about each patent.
Patent issued to IU innovation method that activates T cells in vitro:
The U.S. Patent and Trademark Office has issued a patent for a method developed by Yan Yu, professor in the Department of Chemistry in the College of Arts and Sciences at IU Bloomington, that activates T cells in vitro by biomimetic Janus particles useful as artificial antigen presenting cells. The particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune diseases and viral infection immunotherapy.
Patent issued to IU apparatus and method for speech processing using a neural network:
The U.S. Patent and Trademark Office has issued a patent for an apparatus and method developed by Minje Kim that uses a hybrid neural network. The method converts a noisy speech signal to clean speech directly without time-frequency transformation or mask estimation. An associate professor of intelligent systems engineering in the IU Luddy School of Informatics, Computing and Engineering, Kim has an extensive portfolio in audio and speech technologies; this is the latest issued patent in collaboration with the Electronics and Telecommunications Research Institute.
Patent issued to IU method for forming a gut bioreactor:
The U.S. Patent and Trademark Office has issued a patent for a method for forming a gut bioreactor developed by Jay Lennon, Alexander Gumennik, Louis Alexandre van der Elst, and Emmi Mueller. The gut bioreactor provides bio-printed tissue with realistic microstructure that mimics gut environment and enables the study of the complexity and function of gut microbiome. Lennon is a professor of biology in the College of Arts and Sciences at IU Bloomington. Gumennik is an assistant professor of intelligent systems engineering in the IU Luddy School of Informatics, Computing and Engineering. He also directs the Fibers and Additive Manufacturing Enabled Systems Laboratory (ISE FAMES Lab) in the Luddy School’s Department of Intelligent Systems Engineering.
Patent issued for small molecule antiviral drug treatment for HPV infections:
The U.S. Patent and Trademark Office has issued a patent for an antiviral drug treatment for HPV developed by IU School of Medicine professors Elliot Androphy and Samy Meroueh. The small molecules specifically bind to the HPV E6 protein to inactivate the protein to treat infections including premalignant HPV infections and HPV induced cancers.
Patent issued for method for resolving lipoproteins with mass spectrometry:
The U.S. Patent and Trademark Office has issued a patent for a method of analyzing lipoproteins developed by Martin Jarrold. The Jarrold lab uses charge detection mass spectometry (CDMS) to analyze and resolve lipoprotein subclasses, with the goal of developing better biomarkers for cardiovascular disease. Jarrold is a Distinguished Professor and Robert & Marjorie Mann Chair in the Department of Chemistry in the College of Arts and Sciences at IU Bloomington.
Patent issued for method and system that provides aerial transport network infrastructures for unmanned aerial vehicles:
The U.S. Patent and Trademark Office has issued a patent for a method and system developed by Aniruddha Banerjee, an associate professor of geography in the School of Liberal Arts at IU Indianapolis, that provides a transportation network infrastructure for aerial autonomous vehicles such as drones. The transport network, built on publicly available information, creates a comprehensive retail delivery system with security protocols.
These innovations were disclosed to the IU Innovation and Commercialization Office. The mission of the office is to transfer IU innovations from lab to market for public benefit and global impact. The office files patents to facilitate commercialization of the innovation. IU personnel can disclose an invention online.
Bri Heron, technology marketing manager at Indiana University’s Innovation and Commercialization Office, contributed to this story.