Optical Solutions to Enable New Discoveries in Biology
Optical imaging techniques such as optical coherence tomography (OCT) and fluorescence microscopy (FM) have enabled tremendous biological and clinical research opportunities. However, the need for enhancing technological innovations to allow a better understanding of biological processes (structural and physiological remodeling) involved in developmental and pathological conditions is still manifest. FOIB lab uses a translational research approach from disease understanding using transgenic animal models to disease diagnosis and management on human subjects. The group focuses on developing advanced cellular-level resolution imaging systems, including optical coherence microscopy and integrated OCM and FM, that can track the dynamics of cellular processes in vivo and follow up these processes over time in the same subject. The group is particularly interested in understanding the structural and physiological remodeling of the anterior segment of the eye in disease conditions such as keratoconus, Fuchs endothelial corneal dystrophy, and primary open-angle glaucoma, as well as the long-term effects of contact lenses on corneal microstructures.
Our research interest lies at the frontier of optics, engineering, and biology. It includes anterior segment imaging, light interaction with biological tissue, interferometry, optical metrology, optical coherence tomography, fluorescence microscopy, optical system design, and image processing.
In our research group, we strive to give trainees the opportunity to develop a multidisciplinary skills-set to help them better navigate their future career paths.
Optical Coherence Tomography
Multimodal Imaging System
Transgenic Mouse Imaging
Human Corneal Imaging
Primary Open-angle Glaucoma