• Skip to Content
  • Skip to Sidebar
IU

Indiana University Bloomington Indiana University Bloomington IU Bloomington

Menu

ScIUConversations in Science at Indiana University

  • Home
  • Home
  • About ScIU
  • Write with Us!
  • Contact ScIU
  • The Writers and Editors of ScIU
  • ScIU in the Classroom
  • Annual Science Communication Symposium
  • Search

A change of perspective

Posted on June 1, 2019 by Alexandra Moussa-Tooks and Guest Contributor

One author is ScIU guest writer Melanie Chin, a graduate student in IU’s Department of Biology and Program in Neuroscience.

This post is part of a series featuring amazing science images and the stories behind them. Comment below with your guess and read on to see if you are correct!

There is no argument that the photo below is beautiful, but you might be surprised by what it is depicting. In fact, I might argue that this photo shows us something we encounter almost every day and, unfortunately, is thought of as far less magical and majestic. It is funny how a new perspective really does change our view!

A colorful, symmetrical structure that resembles a butterfly with antennae on a black background.
What could this beautiful structure be!? Read on to find out. Photo taken by Biology and Neuroscience Dual PhD Student Melanie Chin.

First, this image depicts something that is symmetrical and quite colorful. You also might notice that there is a core, some bubbly wings, and something that looks like antennae. So, what is it? An ethereal butterfly?

Before spilling the unbelievable truth, I will first explain what you are seeing in this photo in greater detail. The colors in this image are used to describe the depth of the structures being depicted. In this particular image, blue and cool colors indicate that something is close to the surface, whereas warmer colors indicate deeper structures. The variety of colors in this image indicate that this is something with substantial volume, substance, and structural complexity!

One of these structural complexities is the colored blobs outlining the “wings” — they almost resemble little cells. In fact, that is exactly what they are! More specifically, they are glia, cells in the brain that are not neurons. Traditionally, it was thought to that glia were only present to provide structural support for neurons, like a scaffold; however, recent research shows that this is not the complete story. Now, it is well-established that while glial cells do provide support, they also have a wide array of other critical functions including: (1) maintaining the cellular chemical environment to keep neurons safe, (2) helping neurons conduct electrical signals, and (3) helping in injury recovery by removing harmful substances and repairing or removing dying cells. Due to the variety of purposes glia serve, it may not be surprising that the human nervous system is made up of billions of neurons, but approximately ten times more glial cells!

So, getting back to the image: it depicts a subset of glia in the Drosophila larval brain. The outlines of these circle-shaped glia are prominent and colorful because these cells have been “stained” to show us where a gene called No mechanoreceptor potential-C (nompC) is found.

nompC codes for a mechanosensitive ion channel — a protein that causes a chemical change in neurons when it senses a physical change. For example, when you grip your Starbucks cup, the mechanosensitive ion channels in the skin of your hand actually change shape in response to you touching the cup. In other words, you are physically changing these receptors by pressing the cup against your skin. This change in shape alerts neurons connected to these “activated” channels to send signals from your hand to your brain, telling your brain that you are holding an object.   

In Drosophila (fruit fly) larvae, this protein has a role in maintaining coordination and gentle touch responses, which allow flies to sense something as soft as the touch of an eyelash. This image is the first evidence of its presence in the larval brain, suggesting that nompC may have an undiscovered role in detecting physical changes around the brain surface. You may be asking, why does a brain need to detect these physical changes?

https://blogs.iu.edu/sciu/files/2019/06/LarvaeRolling.mp4

When drosophila larvae are presented with a harmful (noxious) stimuli, such as hot temperature or a sharp object, one type of response they perform is a rolling behavior. In this video, a small larvae is being touched with a thermal (46℃) probe. In response, the larvae rolls. This behavior occurs because sensory receptors allow Drosophila larvae to detect this potentially harmful stimulus and protect themselves.

 

This ability is important because physical changes in the brain could be anything from a mild bump to a high impact event, such as concussion, which arises from the brain being forced at high speeds into the inner surface of the skull — imagine shaking a clump of jello in a jar. The presence of the nompC receptor in the fly brain gives us a possible model to study traumatic brain injury, a very prevalent problem for humans today, in an experimental environment. In the Tracey Lab at IU, we use a simple device to deliver a consistent, high impact traumatic event to fruit flies. We then study the role of genes, including nompC, in this type of traumatic brain injury.

While nompC is not present in the human brain, there are many human proteins with similar properties. In fact, about 75% of human disease-causing genes have an equivalent gene in fruit flies, making them an excellent model to answer scientific questions in a simpler system. Specifically, flies breed quickly, have simple and well-understood DNA and nervous systems, and can be studied in large numbers with minimal ethical concerns compared to mammals, such as rodents or humans. A larger goal of the Tracey Lab is to understand the genetic basis of nociception, or the sensing of painful environmental stimuli. This type of work could lead to the discovery of novel targets for the therapeutic treatment of pain disorders.

This explanation is all to say that this is a picture of a brain — the brain of a larval stage fruit fly — that could provide insight into potential new roles for mechanosensitive ion channels in the fly brain and yours.

Edited by Kat Munley and Lana Ruck

Print Friendly, PDF & Email

Related

Filed under: Cutting-Edge Science at IU, Guess What: Science PicturesTagged Biology, fruit fly, guess what, neuroscience, pain, science images, women in STEM

14 Comments

  1. powerball365.info June 12th, 2021

    Having read this I believed it was extremely informative. I appreciate you finding the time and energy to put this content together. I once again find myself personally spending a significant amount of time both reading and leaving comments. But so what, it was still worth it! powerball365.info

    Reply
  2. racesite.pro June 12th, 2021

    Great web site you have got here.. It’s hard to find quality writing like yours these days. I really appreciate individuals like you! Take care!! 경마사이트

    Reply
  3. casinosite777.info July 13th, 2021

    I do agree with all of the ideas you’ve presented in your post.바카라사이트

    Reply
  4. baccaratsite.top July 13th, 2021

    This article is very helpful and interesting too. 바카라사이트Keep doing this in future. I will support you.

    Reply
  5. sportstoto.zone July 13th, 2021

    it’s awesome and I found this one informative토토사이트

    Reply
  6. baccaratsite.biz July 13th, 2021

    Great blog article. Really looking forward to read more.카지노사이트

    Reply
  7. pharaohcasinonet July 17th, 2021

    Wonderful post with amazing article. I was so impressed to yours.카지노사이트

    Reply
  8. bamgosoocom July 18th, 2021

    You completed several nice points there. I did a search on the issue and found the majority of
    persons will go along with with your blog.
    강남오피
    I know this web site offers quality depending articles or reviews and other information,
    is there any other site which offers such data in quality?

    Reply
  9. 안전놀이터추천 July 24th, 2021

    I feel like I’m becoming a genius because there are so many good writings in the world.안전놀이터추천

    Reply
  10. casinositelink August 7th, 2021

    What a nice article i found , i was looking it for a long time , i been searching it for so long now that i found out really help me.
    바카라사이트

    Reply
  11. margaux May 10th, 2022

    This content is very informative!

    Reply
  12. KIMBERLY MAE MANANSALA May 11th, 2022

    I just wanted to let you know that it’s been great reading your article.

    Reply
  13. cat de lapaz May 12th, 2022

    amazing articles i love it

    Reply
  14. Janine De Leon May 13th, 2022

    great and amazing articles.

    Reply

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Additional Content

Search ScIU

Categories

Tag cloud

#Education #scicomm animal behavior anthropology archaeology astronomy astrophysics Biology biotechnology Black History Month brain cannabinoids cannabis Chemistry climate change conservation coronavirus COVID–19 Diversity in Science diversity in STEM Ecology environment evolution geology history and philosophy of science infectious disease Interdisciplinary Interview Mental Health methods microbiology neuroscience outreach physics Plants primates psychology Research science communication science education Science Outreach science policy Statistics STEM women in STEM

Subscribe

Receive a weekly email with our new content! We will not share or use your information for any other purposes, and you may opt out at any time.

Please, insert a valid email.

Thank you, your email will be added to the mailing list once you click on the link in the confirmation email.

Spam protection has stopped this request. Please contact site owner for help.

This form is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Current Contributors

  • Log in
  • SPLAT
  • ScIU Guides

Indiana University

Copyright © 2022 The Trustees of Indiana University | Privacy Notice | Accessibility Help

  • Home
  • About ScIU
  • Write with Us!
  • Contact ScIU
  • The Writers and Editors of ScIU
  • ScIU in the Classroom
  • Annual Science Communication Symposium
College of Arts + Sciences

Are you a graduate student at IUB? Would you like to write for ScIU? Email sciucomm@iu.edu


Subscribe

Subscribe By Email

Get every new post delivered right to your inbox.

This form is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

 

Loading Comments...