Congratulations to Jenna, Michael, Jackson, and Isaiah on their new publication! This article was the first article with the lab for Jenna and Isaiah! The article examines the EphA2 receptor’s ability to signal canonically via receptor-ligand interaction and non-canonically without ligand binding. Non-canonical EphA2 signaling is typically associated with cancerous cells or tissues. Interestingly, our data is the first demonstration that non-canonical EphA2 signaling is active in normal wild-type lenses, and our results suggest that non-canonical EphA2 signaling has a physiological function. Have a look here: Canonical ligand-dependent and non-canonical ligand-independent EphA2 signaling in the eye lens of wild-type, knockout, and aging mice.
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